Pemphigus: New approaches to diagnosis and disease severity assessment
- 作者: Teplyuk N.1, Kolesova Y.1, Mak D.1, Lepekhova A.1, Toshchakov S.2, Fedotcheva T.3
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隶属关系:
- The First Sechenov Moscow State Medical University (Sechenov University)
- National Research Centre "Kurchatov Institute"
- The Russian National Research Medical University named after N.I. Pirogov
- 期: 卷 26, 编号 5 (2023)
- 页面: 515-526
- 栏目: DERMATOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/232088
- DOI: https://doi.org/10.17816/dv492306
- ID: 232088
如何引用文章
详细
Pemphigus represents a group of severe and potentially fatal autoimmune bullous diseases. Pemphigus clinical findings represents skin and/or mucous membranes keratinocytes acantholysis with intraepithelial blisters and erosions formation which is life-threatening and, if relapsed, significantly reduce the patients’ quality of life. The on-time disease diagnosis is a key to successful pemphigus management and timely treatment onset allowing intensive disease progression avoidance.
The article reviews up-to-date diagnosing methods and assessment measure for monitoring pemphigus severity. In addition to standard diagnosis methods, such as clinical findings, histological examination, direct and indirect immunofluorescence, and enzyme immunoassay (ELISA), the article focuses on revieing new diagnostic and disease severity prediction approaches, such as microRNAs expression and skin and mucous membranes microbiome analysis since false positive and false negative results in histological and immunohistochemical analysis as well as the laboratories insufficient equipment makes finding pemphigus new diagnostic and prognostic methods a relevant challenge.
作者简介
Natalia Teplyuk
The First Sechenov Moscow State Medical University (Sechenov University)
Email: teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN 代码: 8013-3256
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, MoscowYulia Kolesova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: jusamilutin@rambler.ru
ORCID iD: 0000-0002-3617-2555
SPIN 代码: 1441-8730
Graduate Student, Assistant Lecturer
俄罗斯联邦, MoscowDaria Mak
The First Sechenov Moscow State Medical University (Sechenov University)
Email: bedariaaa@gmail.com
ORCID iD: 0000-0002-7020-0572
SPIN 代码: 8204-4555
Graduate Student
俄罗斯联邦, MoscowAnfisa Lepekhova
The First Sechenov Moscow State Medical University (Sechenov University)
Email: anfisa.lepehova@yandex.ru
ORCID iD: 0000-0002-4365-3090
SPIN 代码: 3261-3520
MD, Cand. Sci. (Med.), Associate Professor
俄罗斯联邦, MoscowStepan Toshchakov
National Research Centre "Kurchatov Institute"
编辑信件的主要联系方式.
Email: stepan.toshchakov@gmail.com
ORCID iD: 0000-0001-7549-3450
SPIN 代码: 8994-5224
National Research Centre "Kurchatov Institute"
俄罗斯联邦Tatiana Fedotcheva
The Russian National Research Medical University named after N.I. Pirogov
Email: tfedotcheva@mail.ru
ORCID iD: 0000-0003-4998-9991
SPIN 代码: 1261-5650
MD, Dr. Sci. (Med.), Professor
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