Immune aspects of segmentary and nonsegmentary vitiligo


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The immune status was evaluated in patients with segmentary (SV) and nonsegmentary (NSV) vitiligo and normal subjects. Significant differences were detected between the patients with the two clinical forms. Cellular immunity imbalance was detected in NSVpatients: a more marked reduction of T-lymphocytes and T-helpers paralleled by high suppressor activity. In addition, these patients developed a significant increase in the levels of circulating immune complexes and a reduction of the zero cell levels in comparison with SV patients and controls. The results indicated that different pathogenetic mechanisms led to melanocyte destruction in SV and NSVpatients.

作者简介

L. Sharafutdinova

I.M. Setchenov First Moscow State Medical University

Кафедра кожных и венерических болезней, лечебного факультета; аспирант Moscow, Russia

Konstantin Lomonosov

I.M. Setchenov First Moscow State Medical University

Email: lamdinic@yandex.ru
MD, PhD, DSc, prof. Moscow, Russia

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