Immune aspects of segmentary and nonsegmentary vitiligo


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Abstract

The immune status was evaluated in patients with segmentary (SV) and nonsegmentary (NSV) vitiligo and normal subjects. Significant differences were detected between the patients with the two clinical forms. Cellular immunity imbalance was detected in NSVpatients: a more marked reduction of T-lymphocytes and T-helpers paralleled by high suppressor activity. In addition, these patients developed a significant increase in the levels of circulating immune complexes and a reduction of the zero cell levels in comparison with SV patients and controls. The results indicated that different pathogenetic mechanisms led to melanocyte destruction in SV and NSVpatients.

About the authors

L. A Sharafutdinova

I.M. Setchenov First Moscow State Medical University

Кафедра кожных и венерических болезней, лечебного факультета; аспирант Moscow, Russia

Konstantin M. Lomonosov

I.M. Setchenov First Moscow State Medical University

Email: lamdinic@yandex.ru
MD, PhD, DSc, prof. Moscow, Russia

References

  1. Huggins R.H., Schwartz R.A., Janniger C.K. Vitiligo. Acta Dermatovenerol. Alp. Pannonica Adriat. 2005; 14(4): 137-42.
  2. van Geel N., De Lille S., Vandenhaute S., Gauthier Y., Mollet I., Brochez L., Lambert J. Different phenotypes of segmental vitiligo based on a clinical observational study. J. Eur. Acad. Dermatol. Venereol. 2011; 25(6): 673-8. doi: 10.1111/j.1468-3083.2010.03847.x.
  3. Ахмедов К.Р. Белые пятна кожи. Ташкент: Наука и технология; 2012.
  4. Haug M., Dannecker L., Schepp C.P., Kwok W.W., Wernet D., Buckner J.H., et al. The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells. Eur. J. Immunol. 2005; 35(11): 3163-72.
  5. Naughton G.K., Eisinger M., Bystryn J.C. Antibodies to normal human melanocytes in vitiligo. J. Exp. Med. 1983; 158(1): 246-51.
  6. Li Y.L., Yu C.L., Yu H.S. IgG anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes. J. Invest. Dermatol. 2000; 115(6): 969-73.
  7. Lin I.C., Chen Y.F., Li S.Y., Yang P.Y. Imbalance of peripheral leukocyte and lymphocyte subpopulations in segmental vitiligo in Taiwanese. J. Dermatol. Sci. 2003; 33(3): 189-91.
  8. Hann S.K., Park Y.K., Chung K.Y., Kim H.I., Im S., Won J.H. Peripheral blood lymphocyte imbalance in Koreans with active vitiligo. Int. J. Dermatol. 1993; 32(4): 286-9.
  9. Halder R.M., Walters C.S., Johnson B.A., Chakrabarti S.G. & Kenney J.A. Aberrations in T lymphocytes and natural killer cells in vitiligo: a flow cytometric study. J. Am. Acad. Dermatol. 1986; 14(5, Pt 1): 733-7.
  10. Mozzanica N., Frigerio U., Finzi A.F., Cattaneo A., Negri M., Scaglione F., et al. T cell subpopulations in vitiligo: a chronobiologic study. J. Am. Acad. Dermatol. 1990; 22(2, Pt 1): 223-30.
  11. Gunduz K., Ozturk G., Terzioglu E., Sebik F. T cell subpopulations and IL-2R in vitiligo. J. Dermatol. 2004; 31(2): 94-7.
  12. Khaitan B.K., Kathuria S., Ramam M. A descriptive study to characterize segmental vitiligo. Indian J. Dermatol. Venereol. Leprol. 2012; 78(6): 715-21. doi: 10.4103/0378-6323.102362.
  13. van Geel N., Mollet I., Brochez L., Dutre M., De Schepper S., Verhaeghe E., et al. New insights in segmental vitiligo: case report and review of theories. Br. J. Dermatol. 2012; 166(2): 240-6. doi: 10.1111/j.1365-2133.2011.10650.x.
  14. Zaki M., Elbatrawy A.N. Catecholamine level and its relation to anxiety and depression in patients with vitiligo. J. Egypt. Women Dermatol. Soc. 2009; 6(2): 74-9.
  15. Dhabbar F.S., Miller A.H., Stein M., McEwen B.S., Spencer R.L. Diurnal and acute stress-induced changes in distribution of peripheral blood leukocyte subpopulations. Brain. Behav. Immun. 1994; 8(1): 66-79.
  16. Rajashekar T.S., Singh G., Rajkumar V. Segmental vitiligo and twentynail dystrophy: an unusual association. Indian J. Dermatol. Venereol. Leprol. 2008; 74(6): 661-2.
  17. Sardana K., Sharma R.C., Koranne R.V., Mahajan S. An interesting case of colocalization of segmental lichen planus and vitiligo in a 14-year-old boy. Int. J. Dermatol. 2002; 41(8): 508-9.
  18. Bonifati C., Impara G., Morrone A., Pietrangeli A., Carducci M. Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. J. Eur. Acad. Dermatol. Veneorol. 2006; 20(1): 63-5.

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