MicroRNA as a diagnostic marker in cutaneous T-cell lymphomas
- Authors: Olisova O.Y.1, Demkin V.V.2, Chernova N.G.3, Amshinskaya J.R.1, Kazakov A.A.2
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Institute of Molecular Genetics of the Russian Academy of Sciences
- City Clinical Hospital № 40
- Issue: Vol 25, No 1 (2022)
- Pages: 5-16
- Section: DERMATO-ONCOLOGY
- URL: https://journals.rcsi.science/1560-9588/article/view/106327
- DOI: https://doi.org/10.17816/dv106327
- ID: 106327
Cite item
Abstract
BACKGROUND: In recent years, thanks to the development of methods of molecular genetic analysis, microRNA has become one of the promising markers for the diagnosis of many human diseases.
AIMS: to study microRNA as a new method for the diagnosis of fungal mycosis.
MATERIALS AND METHODS: The study included 30 patients with histologically confirmed diagnosis of T-cell lymphomas of the skin, 25 were diagnosed with fungal mycosis, 5 ― Cesari syndrome. The control group consisted of 10 patients with benign lymphoproliferative dermatoses. The patients underwent the determination of microRNA 223, 16, 326, 663, 423, 711 in blood plasma. MicroRNA was also detected in plasma in patients with T-cell lymphomas of the skin at early and late stages.
RESULTS: Statistically significant difference of 223, 16, 326, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis, compared with patients with benign lymphoproliferative dermatoses. Statistically significant difference of 663 microRNA in blood plasma was revealed in patients with T-cell lymphomas of the skin at early and late stages. A statistically significant difference of 223, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis at an early stage compared with patients with benign lymphoproliferative dermatoses.
CONCLUSION: The determination of microRNA 223, 16, 326, 711 in blood plasma can be used for early diagnosis of T-cell lymphomas of the skin.
Keywords
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##article.viewOnOriginalSite##About the authors
Olga Yu. Olisova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowVladimir V. Demkin
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: vdemkin@img.ras.ru
ORCID iD: 0000-0002-3408-6100
SPIN-code: 5130-8270
MD, Cand. Sci. (Med.)
Russian Federation, MoscowNatalia G. Chernova
City Clinical Hospital № 40
Email: ngchernova@mail.ru
ORCID iD: 0000-0002-0827-4052
SPIN-code: 2683-1517
MD, Cand. Sci. (Med.)
Russian Federation, MoscowJessika R. Amshinskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: dr.jessika@yandex.ru
ORCID iD: 0000-0002-3907-2189
SPIN-code: 6770-5019
Graduate Student
Russian Federation, MoscowAndrey A. Kazakov
Institute of Molecular Genetics of the Russian Academy of Sciences
Email: andrey20079@mail.ru
ORCID iD: 0000-0002-5559-6003
Russian Federation, Moscow
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