MicroRNA as a diagnostic marker in cutaneous T-cell lymphomas

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Abstract

BACKGROUND: In recent years, thanks to the development of methods of molecular genetic analysis, microRNA has become one of the promising markers for the diagnosis of many human diseases.

AIMS: to study microRNA as a new method for the diagnosis of fungal mycosis.

MATERIALS AND METHODS: The study included 30 patients with histologically confirmed diagnosis of T-cell lymphomas of the skin, 25 were diagnosed with fungal mycosis, 5 ― Cesari syndrome. The control group consisted of 10 patients with benign lymphoproliferative dermatoses. The patients underwent the determination of microRNA 223, 16, 326, 663, 423, 711 in blood plasma. MicroRNA was also detected in plasma in patients with T-cell lymphomas of the skin at early and late stages.

RESULTS: Statistically significant difference of 223, 16, 326, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis, compared with patients with benign lymphoproliferative dermatoses. Statistically significant difference of 663 microRNA in blood plasma was revealed in patients with T-cell lymphomas of the skin at early and late stages. A statistically significant difference of 223, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis at an early stage compared with patients with benign lymphoproliferative dermatoses.

CONCLUSION: The determination of microRNA 223, 16, 326, 711 in blood plasma can be used for early diagnosis of T-cell lymphomas of the skin.

About the authors

Olga Yu. Olisova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Vladimir V. Demkin

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: vdemkin@img.ras.ru
ORCID iD: 0000-0002-3408-6100
SPIN-code: 5130-8270

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Natalia G. Chernova

City Clinical Hospital № 40

Email: ngchernova@mail.ru
ORCID iD: 0000-0002-0827-4052
SPIN-code: 2683-1517

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Jessika R. Amshinskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: dr.jessika@yandex.ru
ORCID iD: 0000-0002-3907-2189
SPIN-code: 6770-5019

Graduate Student

Russian Federation, Moscow

Andrey A. Kazakov

Institute of Molecular Genetics of the Russian Academy of Sciences

Email: andrey20079@mail.ru
ORCID iD: 0000-0002-5559-6003
Russian Federation, Moscow

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2. Fig. 1. Sensitivity and specificity analysis mir223.

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3. Fig. 2. Sensitivity and specificity analysis mir16.

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Copyright (c) 2022 Olisova O.Y., Demkin V.V., Chernova N.G., Amshinskaya J.R., Kazakov A.A.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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