Relationship between the level of vitamin D in bloof flow and skin dermatosis

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Abstract

Vitamin D is vital for bone health and its deficiency deemed as a disease of the past has re-emerged as an important health concern. Thanks to modern research, the role of vitamin D has been studied in detail and goes far beyond the concepts of regulating the mineral composition of bones. A small amount of active vitamin in the form of cholecalciferol is obtained by the body with food of animal origin, in the form of ergocalciferol and previtamin D ― with food of plant origin. Another way to get vitamin D is exposure to solar radiation. Both insufficient and excessive levels of vitamin D have adverse effects on the body. A constant blood level above 200 ng/ml is considered toxic and is manifested by anorexia, weight loss, polyuria and cardiac arrhythmia. Vitamin D toxicity increases the risk of kidney stones, calcification of blood vessels and tissues, as well as complications associated with these changes.

The growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and cutaneous dermatoses. Undoubtedly, a complete understanding of the synthesis of vitamin D, the main sources of its production by the body, indicators of the normal content of vitamin D levels in the blood, as well as factors that can influence their changes, are important. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer.

Also of interest is the importance of vitamin D as adjuvant therapy in patients on long-term treatment with corticosteroids. In this review, we provide an overview of the most important and most recent information regarding the relationship between vitamin D and skin disease and discuss the importance of assessing individual vitamin D status and correcting deficiencies.

About the authors

Elena A. Morozova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: doc.elene@mail.ru
ORCID iD: 0000-0001-5826-5018
SPIN-code: 4437-3800

MD, Cand. Sci. (Med.), Assistant Lecturer

Russian Federation, 4, building 1 st. Bolshaya Pirogovskaya, Moscow, 119435

Ekaterina V. Kurdyukova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: katrin_45_34@mail.ru
ORCID iD: 0000-0001-7723-8701
SPIN-code: 9506-0978

Student

Russian Federation, Moscow

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