T-cell receptor repertory in some immunassociated dermatoses


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Abstract

The repertory of T-cell receptors in some immunassociated cutaneous disease is presented. We studied the T-cell receptor variety in involved and intact skin and in the blood of patients with psoriasis and atopic dermatitis and the time course of these receptors during immunosuppressive therapy by massive sequencing methods, in order to detect the probable specific antigen as a potential target for developing new methods for effective therapy of these diseases.

About the authors

A. A Paramonov

I.M. Setchenov First Moscow State Medical University

Email: paramonov_aleksey@mail.ru
Department of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Faculty 119991, Moscow, Russia

L. N Kayumova

I.M. Setchenov First Moscow State Medical University

Email: avestohka2005@inbox.ru
Department of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Faculty 119991, Moscow, Russia

S. A Bruskin

N.I. Vavilov Institute of Genetics

Email: brouskin@vigg.ru
кандидат биол. наук, доцент 119333, Moscow, Russia

Nicolay G. Kochergin

I.M. Setchenov First Moscow State Medical University

Email: nkocha@yandex.ru
MD, PhD, DSc, prof. 119991, Moscow, Russia

O. Yu Olisova

I.M. Setchenov First Moscow State Medical University

Email: olisovaolga@mail.ru
Department of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Faculty 119991, Moscow, Russia

M. N Ostretsova

I.M. Setchenov First Moscow State Medical University

Email: mostretsova@gmail.com
Department of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Faculty 119991, Moscow, Russia

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