Репертуар Т-клеточных рецепторов при некоторых иммунозависимых дерматозах


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Аннотация

Представлены результаты исследований по изучению многообразия (репертуара) Т-клеточных рецепторов при некоторых иммунозависимых кожных заболеваниях. В нашем исследовании изучен репертуар Т-клеточных рецепторов в пораженной и непораженной коже, а также в крови при псориазе и атопическом дерматите, а также установлен характер изменений данного репертуара у больных в ходе иммуносупрессивной терапии при помощи методов массивного секвенирования с целью выявления возможного специфического антигена в качестве потенциальной мишени для разработки новых методов эффективной терапии данных заболеваний.

Об авторах

Алексей Александрович Парамонов

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: paramonov_aleksey@mail.ru
Кафедра кожных и венерических болезней лечебного факультета; аспирант 119991, Москва, Россия

Ляиля Наилевна Каюмова

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: avestohka2005@inbox.ru
Кафедра кожных и венерических болезней лечебного факультета; аспирант 119991, Москва, Россия

Сергей Александрович Брускин

ФГБУН Институт общей генетики им. Н.И. Вавилова РАН

Email: brouskin@vigg.ru
кандидат биол. наук, доцент 119333, Москва, Россия

Николай Георгиевич Кочергин

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: nkocha@yandex.ru
доктор мед. наук, профессор 119991, Москва, Россия

Ольга Юрьевна Олисова

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: olisovaolga@mail.ru
Кафедра кожных и венерических болезней лечебного факультета; доктор мед. наук, профессор 119991, Москва, Россия

Мария Николаевна Острецова

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России

Email: mostretsova@gmail.com
Кафедра кожных и венерических болезней лечебного факультета; аспирант 119991, Москва, Россия

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