Unilateral dermatoses: Relationship with Blashko's lines and neurological changes


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Abstract

Blashko’s lines correspond to the mutant cell migration and proliferation routes during embryogenesis. Unilateral dermatoses (UD), congenital and acquired ones, are located along Blashko’s lines. The term UD is more often used in Russian publications. Segmented, linear, blashkoid, or Blashko line dermatoses are the terms used by foreign specialists. The skin mosaicism theory is now confirmed at the cell level for at least 15 dermatoses, including nevoid andX-linked dermatoses. However, the pathogenetic mechanism of unilateral location inacquired UD remains unclear. Monolateral involvement may be observed in type I segmented mosaicism in autosomal dominant diseases. On the other hand, some authors explain the unilateral location of these dermatoses by involvement of the central and peripheral nervous system.

About the authors

Olga Yu. Olisova

I.M. Setchenov First Moscow Medical University

Email: olisovaolga@mail.ru
MD, PhD, DSc, prof. 119991, Moscow, Russia

O. V Grabovskaya

I.M. Setchenov First Moscow Medical University

Email: olgadoctor@mail.ru
Кафедра кожных и венерических болезней; кандидат мед. наук, доцент 119991, Moscow, Russia

N. P Teplyuk

I.M. Setchenov First Moscow Medical University

Email: Teplyukn@gmail.com
Кафедра кожных и венерических болезней; доктор мед. наук, профессор 119991, Moscow, Russia

T. A Belousova

I.M. Setchenov First Moscow Medical University

Email: belka-1147@mail.ru
Кафедра кожных и венерических болезней; кандидат мед. наук, доцент 119991, Moscow, Russia

V. A Varshavsky

I.M. Setchenov First Moscow Medical University

Email: vavarsh@mma.ru
кафедра патологической анатомии; доктор мед. наук, профессор 119991, Moscow, Russia

N. S Arsentyev

I.M. Setchenov First Moscow Medical University

Email: kolendra@mail.ru
лечебно-диагностическое отделение Университетской клинической больницы №2 клиника кожных и венерических болезней им. В.А. Рахманова; врач 119991, Moscow, Russia

N. G Shpitalnikova

I.M. Setchenov First Moscow Medical University

Email: shpitalnikova@mail.ru
лечебно-диагностическое отделение Университетской клинической больницы №1 лечебного факультета; врач-невролог 119991, Moscow, Russia

I. S Dzhavakhishvili

I.M. Setchenov First Moscow Medical University

Email: irusa-irusa@yandex.ru
Кафедра кожных и венерических болезней; аспирант 119991, Moscow, Russia

P. M Pyatilova

I.M. Setchenov First Moscow Medical University

Email: pypolina@mail.ru
Кафедра кожных и венерических болезней; ординатор 119991, Moscow, Russia

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