Cyclosporine A in dermatology


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Abstract

Published data on cyclosporine A mechanism of action, treatment protocols, side effects, and combinations with other drugs are reviewed. Clinical data on the efficiency of the immunosuppressant, used in modern practical dermatology for therapy ofpsoriasis, atopic dermatitis, pemphigus vulgaris, alopecia areata, etc., are presented. Published data indicate high efficiency of cyclosporine A in the treatment of these diseases. Positive effects of the drug on the involved skin and induction of clinical remission in response to treatment are described.

About the authors

Lusine G. Garanyan

I.M. Setchenov First Moscow Medical University

Email: lusine90@list.ru
Кафедра кожных и венерических болезней лечебного факультета, клинический ординатор 119991, Moscow, Russia

D. V Avagyan

I.M. Setchenov First Moscow Medical University

Email: dgemma_90@mail.ru
Кафедра кожных и венерических болезней лечебного факультета, клинический ординатор 119991, Moscow, Russia

References

  1. Молочков В.А., Бадокин В.В., Альбанова В.И., Волнухин В.А. Псориаз и псориатический артрит. М.: Авторская академия; 2007: 79-85.
  2. Ho V.C., Griffiths C.E., Albrecht G., Vanaclocha F., Leon-Dorantes G., Atakan N., et al. Intermittent short courses ofcyclosporin (Neoral) for psoriasis unresponsive to topical therapy: a 1-year multicentre, randomized study. Br. J. Dermatol. 1999; 141(2): 283-91.
  3. Griffiths C.E., Katsambas A., Dijkmans B.A., Finlay A.Y., Ho V.C., Johnston A., et al. Update on the use of ciclosporin in immunemediated dermatoses. Br. J. Dermatol. 2006; 155 (Suppl. 2): 1-16.
  4. Kurzeja M., Rudnicka L., Olszewska M. New interleukin-23 pathway inhibitors in dermatology: ustekinumab, briakinumab, and secukinumab. Am. J. Clin. Dermatol. 2011; 12(2): 113-25. doi: 10.2165/11538950-000000000-00000.
  5. Salvarani C., Boiardi L., Macchioni P., Pipitone N., Catanoso M., Pigatto P. Multidisciplinary focus on cyclosporin A. J. Rheumatol. 2009; 83(Suppl.): 52-5. doi: 10.3899/jrheum.090225
  6. Ho V.C., Griffiths C.E., Albrecht G., Vanaclocha F., Leon-Dorantes G., Atakan N., et al. Intermittent short courses ofcyclosporin (Neoral) for psoriasis unresponsive to topical therapy: a 1-year multicentre, randomized study. Br. J. Dermatol. 1999; 141(2): 283-91.
  7. Salvarani C., Macchioni P., Olivieri I., Marchesoni A., Cutolo M., Ferraccioli G., et al. A comparison of cyclosporin, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. J. Rheumatol. 2001; 28(10): 2274-82.
  8. Raffayova H., Rovensky J., Malis F. Treatment with cyclosporin in patients with psoriatic arthritis: results of clinical assessment. Int. J. Clin. Pharmacol. Res. 2000; 20(1-2): 1-11.
  9. Sarzi-Puttini P., Cazzola M., Panni B., Turiel M., Fiorini T., Belai-Beyene N., Cherie-Ligniere E.L. Long-term safety and efficacy of low-dose cyclosporin A in severe psoriatic arthritis. Rheumatol. Int. 2002; 21(6): 234-8.
  10. Macchioni P., Boiardi L., Cremonesi T., Battistel B., Casadei-Maldini M., Beltrandi E., et al. The relationship between serumsoluble interleukin-2 receptor and the radiological progression in psoriatic arthritis patient treated with cyclosporin-A. Rheumatol. Int. 1998; 18(1): 27-33.
  11. Lawson C.A., Fraser A., Veale D.J., Emery P. Cyclosporin treatment in psoriatic arthritis: a cause of severe leg pain. Ann. Rheum. Dis. 2003; 62(5): 489.
  12. Kamarashev J., Lor P., Forster A., Heinzerling L., Burg G., Nestle F.O. Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumor necrosis factor alpha inhibitor etanercept. Dermatology. 2002; 205(2): 213-6.
  13. Koo J. Neoral in psoriasis therapy: toward a new perspective. Int. J. Dermatol. 1997; 36(Suppl. 1): 25-9.
  14. Harper J.I., Ahmed I., Barclay G., Lacour M., Hoeger.P, Cork M.J., et al. Cyclosporine for severe childhood atopic dermatitis: short course versus continuous therapy. Br. J. Dermatol. 2000; 142 (1): 52-8.
  15. Schmitt J., Schmitt N., Meurer M. Cyclosporin in the treatment of patients with atopic eczema - a systematic review and metaanalysis. J. Eur. Acad. Dermatol. Venereol. 2007; 21(5): 606-19.
  16. Lever W.F., Schaumburg-Lever G. Treatment of pemphigus vulgaris. Results obtained in 84 patients between 1961 and 1982. Arch. Dermatol. 1984; 120(1): 44-7.
  17. Tsuruta D., Ishii N., Hashimoto T. Diagnosis and treatment of pemphigus. Immunotherapy. 2012; 4(7): 735-45. doi: 10.2217/imt.12.67.
  18. Jablonska S., Chorzelski T., Blaszczyk M. Immunosuppressants in the treatment of pemphigus. Br. J. Dermatol. 1970; 83(2): 315-23.
  19. Joly P., Sin C. Pemphigus: a review. Ann. Dermatol. Venereol. 2011; 138(3): 182-200. doi: 10.1016/j.annder.2011.01.016.
  20. Sala F., Berti E., Crosti C. Hallopeau’s pemphigus vegetans. Description of a clinical case. G. Ital. Dermatol. Venereol. 1985; 120(2): 141-4.
  21. Matkaluk R.M., Bailin P.L. Penicillamine-induced pemphigus foliaceus. A fatal outcome. Arch. Dermatol. 1981; 117(3): 156-7.
  22. Gupta A.K., Ellis C.N., Cooper K.D., Nickoloff B.J., Ho V.C., Chan L.S., et al. Oral cyclosporine for the treatment of alopecia areata. A clinical and immunohistochemical analysis. J. Am. Acad. Dermatol. 1990; 22 (2, Pt 1): 242-50.
  23. Gupta A.K., Ellis C.N., Nickoloff B.J., Goldfarb M.T., Ho V.C., Rocher L.L., et al. Oral cyclosporine in the treatment of inflammatory and noninflammatory dermatoses. A clinical and immunopathologic analysis. Arch. Dermatol. 1990; 126(3): 339-50.
  24. Harpenau L.A., Plemons J.M., Rees T.D. Effectiveness of a low dose of cyclosporine in the management of patients with oral erosive lichen planus. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1995; 80(2): 161-7.
  25. Jungell P., Malmstrom M. Cyclosporin A mouthwash in the treatment of oral lichen planus. Int. J. Oral Maxillofac. Surg. 1996; 25(1): 60-2.
  26. Paquet P., Pierard G.E. Severe chronic actinic dermatitis treated with cyclosporine: 2 cases. Ann. Dermatol. Venereol. 2001; 128(1): 42-5.
  27. Barthel H.R., Charrier U., Kramer M., Loch C. Successful treatment of idiopathic febrile panniculitis (Weber-Christian disease) with thalidomide in a patient having failed multiple other medical therapies. J. Clin. Rheumatol. 2002; 8(5): 256-9.
  28. Сучкова Т.Н., Гамаюнов Б.Н., Попов И.В., Тихомиров А.А. Болезнь Пфейфера-Вебера-Крисчена (спонтанный панникулит) у девочки подростка. В кн.: Тезисы III Всероссийского конгресса дерматовенерологов. Казань, 2009.
  29. Entzian P., Barth J., Monig H., Ohnhaus E.E., Kirch W. Treatment of Weber-Christian panniculitis with cyclosporine A. Rheumatol. Int. 1987; 7(4): 181.
  30. Pongratz G., Ehrenstein B., Hartung W., Scholmerich J., Fleck M. A patient with Pfeifer-Weber-Christian disease - successful therapy with cyclosporin A: case report. BMC Musculoskeletal Disord. 2010; 11: 18. doi: 10.1186/1471-2474-11-18.
  31. Hinata M., Someya T., Yoshizaki H., Seki K., Takeuchi K. Successful treatment of steroid-resistant Weber-Christian disease with biliary ductopenia using cyclosporin A. Rheumatology (Oxford). 2005; 44(6): 821-3.
  32. Прохоренков В.И., Гузей Т.Н., Гасич Н.А. Случай панникулита Вебера - Крисчена у ребенка раннего возраста. Вестник дерматологии и венерологии. 2004; 2: 34-7.
  33. Молочков В.А., Сапронова Т.И. Тигазон в терапии болезни Девержи. Российский журнал кожных и венерических болезней. 1999; 3: 27-9.
  34. Wetzig T., Sticherling M. Juvenile pityriasis rubra pilaris: successful treatment with ciclosporin. Br. J. Dermatol. 2003; 149(1): 202-3.
  35. Белявичене Г.Р. Течение и лечение приобретенного буллезного эпидермолиза и рубцующего пемфигоида. Вестник дерматологии и венерологии. 1983; 8: 47-53.
  36. Кряжева С.С., Махнева Н.В. Успешное лечение приобретенного эпидермолиза преднизолоном и сандиммуном. Российский журнал кожных и венерических болезней. 1999; 1: 38-44.
  37. Arevalo J.M., Lorente J.A., Gonzalez-Herrada C., Jimenez-Reyes J. Treatment of toxic epidermal necrolysis with cyclosporin A. J. Trauma. 2000; 48(3): 473-8.
  38. Nussenblatt R.B., Rodrigues M.M., Salinas-Carmona M.C., Gery I., Cevario S., Wacker W. Modulation of experimental autoimmune uveitis with cyclosporin A. Arch. Ophthalmol. 1982; 100(7): 1146-9.

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