Translation cellular immunotherapy of idiopathic and immunosuppressive Kaposi's sarcoma


Cite item

Full Text

Abstract

Translation cellular immunotherapy with ammifurine photosensitizer and UV irradiation (spectrum A) of cellular mononuclear suspension (λ = 320-340 nm, 90 min), followed by its reinfusion, were carried out in 20 patients with Kaposi’s sarcoma (15 with the idiotypical and 5 with immunosuppressive type) aged 32-75 years. Evaluation of the immune status of patients, including phenotyping, was carried out before and after therapy and demonstrated the treatment efficiency, shown by the time course of the clinical picture and periods of disease remission. The treatment efficiency is explained by induction of antitumor immunological surveillance. Relevant publications (8 references) are discussed.

About the authors

M. G Kartashova

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

Email: maxa.ka@mail.ru
кандидат мед. наук, научный сотрудник

A. V Kildyushevsky

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

доктор мед. наук, профессор, ведущий научный сотрудник

A. V Molochkov

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

доктор мед. наук, профессор

V. A Fedulkina

M.F. Vladimirsky Moscow Regional Research and Clinical Institute

References

  1. Молочков А.В., Казанцева И.А., Гурцевич В. Э. Саркома Капоши. М.: БИНОМ; 2000.
  2. Moore P.S., Gao S.J., Dominguez G., Cesarman E., Lungu O., Knowles D.M., et al. Primary characterization of a herpesvirus agent associated with Kaposi’s sarcoma. J. Virol. 1996; 70(1): 549-58.
  3. Renne R., Zhong W., Herndier B., McGrath M., Abbey N., Kedes D.,, Ganem D. Lytic growth of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 1996; 2(3): 342-6.
  4. Luger T.A., Schwarz T., Krutmann J., Kock A., Urbanski A., Kirnbauer R. Cytokinesand theskin. Curr. Probl. Dermatol. 1990; 19: 35-49.
  5. Кильдюшевский А.В., Молочков В А., Ольшанский А.Я., Молочков А.В., Фомин А.М., Гордиевская М.С. и др. Способ лечения Т-клеточных лимфом и саркомы Капоши. Патент № 2401671 от 20.10.2010. Изобретения и полезные модели. 2010; 29.
  6. Timmerman J.M., Levy R. Dendritic cell vaccines for cancer immunotherapy. Annu. Rev. Med. 1999; 50: 507-29.
  7. Aichele P., Brduscha-Riem K., Zinkernagel R.M., Hengartner H., Pircher H. T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 1995; 182(1): 261-6.
  8. Marincola F.M., Jaffee E.M., Hicklin D.J., Ferrone S. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 2000; 74: 181-273.

Copyright (c) 2013 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies