Synthesis of Hybrid Compounds on the Basis of 4-[(1-Oxo-3,4-dihydro-2H-naphthalen-2-ylidene)methyl]benzoic acid
- Autores: Ivanova A.L.1, Kanevskaya I.V.1, Fedotova O.V.1
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Afiliações:
- Institute of Chemistry
- Edição: Volume 55, Nº 8 (2019)
- Páginas: 1231-1233
- Seção: Short Communications
- URL: https://journals.rcsi.science/1070-4280/article/view/221122
- DOI: https://doi.org/10.1134/S1070428019080244
- ID: 221122
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Resumo
The reactions of 4-[(1-oxo-3,4-dihydro-2H-naphmalen-2-ylidene)methyl]benzoic acid with 3-(1,3-dioxobutane-1-yl)-2H-chromen-2-one in the presence of nitrogenous bases (piperidine, triethylamine or pyridine) were used to synthesize for the first time hybrid systems containing the pharmacophoric fragments of the reagents. The reaction scheme involves formation of a condensed dihydropyran structure and its subsequent aromatization into a benzodihydrochromenilium salt under the action of HCl. The process may be accompanied by the competing addition of an azanucleophile by the double bond of the chalcone.
Sobre autores
A. Ivanova
Institute of Chemistry
Autor responsável pela correspondência
Email: aleksandraleonodovna@gmail.com
Rússia, ul. Astrakhanskaya 83, Saratov, 410012
I. Kanevskaya
Institute of Chemistry
Email: aleksandraleonodovna@gmail.com
Rússia, ul. Astrakhanskaya 83, Saratov, 410012
O. Fedotova
Institute of Chemistry
Email: aleksandraleonodovna@gmail.com
Rússia, ul. Astrakhanskaya 83, Saratov, 410012
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