Email this article Synthesis of 2-Substituted 6-(Polyfluoromethyl)pyrimidine-4-carbaldehyde Acetals
- Authors: Belyaev D.V.1, Chizhov D.L.1, Rusinov G.L.1,2, Charushin V.N.1,2
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Affiliations:
- Postovskii Institute of Organic Synthesis, Ural Branch
- Yeltsin Ural Federal University
- Issue: Vol 55, No 6 (2019)
- Pages: 879-882
- Section: Short Communications
- URL: https://journals.rcsi.science/1070-4280/article/view/220794
- DOI: https://doi.org/10.1134/S1070428019060204
- ID: 220794
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Abstract
Heterocyclization of 5,5-difluoro- and 5,5,5-trifluoro-2,4-dioxopentanal dimethyl acetals with amidines in the presence of 4 equiv of triethyl borate afforded 2-substituted 6-(difluoromethyl)- and 6-(trifluoromethyl)pyrimidine-4-carbaldehyde dimethyl acetals in high yields.
About the authors
D. V. Belyaev
Postovskii Institute of Organic Synthesis, Ural Branch
Email: dlchizhov@ios.uran.ru
Russian Federation, Yekaterinburg
D. L. Chizhov
Postovskii Institute of Organic Synthesis, Ural Branch
Author for correspondence.
Email: dlchizhov@ios.uran.ru
Russian Federation, Yekaterinburg
G. L. Rusinov
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: dlchizhov@ios.uran.ru
Russian Federation, Yekaterinburg; Yekaterinburg
V. N. Charushin
Postovskii Institute of Organic Synthesis, Ural Branch; Yeltsin Ural Federal University
Email: dlchizhov@ios.uran.ru
Russian Federation, Yekaterinburg; Yekaterinburg
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