Synthesis of 2-Cyanoethoxy and 2-(1 H -Tetrazol-5-yl)ethoxy Derivatives of Glycyrrhetic Acid Methyl Ester

A. D. Zorina; V. L. Polozova; S. A. Marchenko; S. I. Selivanov; R. E. Trifonov

doi:10.1134/S1070428018120278

Synthesis of 2-Cyanoethoxy and 2-(1H-Tetrazol-5-yl)ethoxy Derivatives of Glycyrrhetic Acid Methyl Ester

Authors: Zorina A.D.¹, Polozova V.L.¹, Marchenko S.A.¹, Selivanov S.I.¹, Trifonov R.E.¹
Affiliations:
1. St. Petersburg State University
Issue: Vol 54, No 12 (2018)
Pages: 1868-1870
Section: Short Communications
URL: https://journals.rcsi.science/1070-4280/article/view/219667
DOI: https://doi.org/10.1134/S1070428018120278
ID: 219667

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Abstract

Cyanoethylation of natural glycyrrhetic acid methyl ester gave the corresponding 3β-O-(2-cyanoethyl) derivative which was treated with sodium azide to obtain a novel tetrazolyl derivative of biologically active triterpenoid, methyl 3β-[2-(1H-tetrazol-5-yl)ethoxy]-11-oxoolean-12-en-30-oate.