Synthesis of spiro[furo[3,4-b]pyran-4,3′-pyrroles] by reaction of pyrrolediones with malononitrile and tetronic acid

Abstract

Substituted ethyl 2-amino-3-cyano-2′,5-dioxo-5′-phenyl-1′,2′,5,7-tetrahydrospiro[furo[3,4-b]pyran-4,3′-pyrrole]-2′-carboxylates were synthesized by one-pot reaction of ethyl 2-phenyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-3-carboxylates with malononitrile and furan-2,4(3H,5H)-dione.