Use of Specific Properties of Poly-N-vinylcaprolactam in Immunochemical Reactions
- Authors: Chikhacheva I.P.1, Shumova T.B.1, Khokhlachev O.F.2, Novikova O.B.2
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Affiliations:
- Moscow University of Technology (Institute of Fine Chemical Technologies)
- All-Russia Research Veterinary Institute of Poultry Farming, Branch of the All-Russia Research and Technological Institute of Poultry Farming
- Issue: Vol 91, No 2 (2018)
- Pages: 325-329
- Section: Macromolecular Compounds and Polymeric Materials
- URL: https://journals.rcsi.science/1070-4272/article/view/215684
- DOI: https://doi.org/10.1134/S1070427218020246
- ID: 215684
Cite item
Abstract
Principal possibility of using a smart polymer, poly-N-vinylcaprolactam, for immobilization of biopharmaceuticals (antibodies and antigens) in the course of phase transition of a soluble coil into an insoluble globule was demonstrated. A procedure for preparing a hydrosol stable at room temperature in the presence of a stabilizer was examined. The hydrosol obtained, in which the collapsed polymer with the captured antigen acts as a solid support, can be used for agglutination with a complementary antibody, i.e., the immunochemical reaction can be evaluated visually.
About the authors
I. P. Chikhacheva
Moscow University of Technology (Institute of Fine Chemical Technologies)
Author for correspondence.
Email: chipova1941@mail.ru
Russian Federation, pr. Vernadskogo 86, Moscow, 119571
T. B. Shumova
Moscow University of Technology (Institute of Fine Chemical Technologies)
Email: chipova1941@mail.ru
Russian Federation, pr. Vernadskogo 86, Moscow, 119571
O. F. Khokhlachev
All-Russia Research Veterinary Institute of Poultry Farming, Branch of the All-Russia Research and Technological Institute of Poultry Farming
Email: chipova1941@mail.ru
Russian Federation, St. Petersburg, 198412
O. B. Novikova
All-Russia Research Veterinary Institute of Poultry Farming, Branch of the All-Russia Research and Technological Institute of Poultry Farming
Email: chipova1941@mail.ru
Russian Federation, St. Petersburg, 198412
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