Synthesis of New 1,3,4-Oxadiazole-benzimidazole Derivatives as Potential Antioxidants and Breast Cancer Inhibitors with Apoptosis Inducing Activity
- 作者: Abd El-Meguid E.1, Awad H.2, Anwar M.3
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隶属关系:
- Department of Chemistry of Natural and Microbial Products
- Department of Tanning Materials and Leather Technology
- Department of Therapeutic Chemistry
- 期: 卷 89, 编号 2 (2019)
- 页面: 348-356
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222770
- DOI: https://doi.org/10.1134/S1070363219020282
- ID: 222770
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详细
Synthesis of new compounds combining benzimidazole with 1,3,4-oxadiazole functionalized by various alkyl and heterocyclic moieties is studied. The new hybrids were evaluated as DPPH radical scavengers and antioxidants. The most active compounds 1, 2, 3a, 3c, and 5d were tested as anticancer agents against MCF-7 and MDA-MB-231 breast cancer cells. The biological study demonstrated significant sensitivity of both types of cancer cells towards the synthesized compounds in comparison with erlotinib used as a reference drug. Cell cycle and apoptosis analysis indicated compound 5d as the one inducing G2/M phase arrest and apoptosis in MCF-7 and MDA-MB-231 cancer cells, in addition to its upregulation of caspases-3 and caspases-9.
作者简介
E. Abd El-Meguid
Department of Chemistry of Natural and Microbial Products
编辑信件的主要联系方式.
Email: manal.hasan52@live.com
埃及, Dokki, Cairo, 12622
H. Awad
Department of Tanning Materials and Leather Technology
Email: manal.hasan52@live.com
埃及, Dokki, Cairo, 12622
M. Anwar
Department of Therapeutic Chemistry
Email: manal.hasan52@live.com
埃及, Dokki, Cairo, 12622