Comparative Studies on DNA Binding, Photocleavage, and Photophysical Properties of Ru(II) Complexes Containing TIP {TIP = 2-(Thiophen-2-yl)-1H-imidazo[4,5-f][1,10]-phenanthroline} Ligand
- 作者: Srinivas G.1,2, Ravi Kumar V.1, Laxma Reddy K.3, Praveen Kumar Y.4, Satyanarayana S.1
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隶属关系:
- Department of Chemistry, University College of Science
- Department of Chemistry, Government Degree College Manthani
- Department of Chemistry, University College of Technology
- Department of Chemistry
- 期: 卷 88, 编号 12 (2018)
- 页面: 2621-2627
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222606
- DOI: https://doi.org/10.1134/S1070363218120253
- ID: 222606
如何引用文章
详细
A thiophene contained imidazo phenanthroline ligand TIP {TIP = 2-(thiophen-2-yl)-1H-imidazo-[4,5-f][1,10]phenanthroline{ and its mononuclear Ru(II) polypyridyl complexes [Ru(phen)2TIP]2+ (1) (phen = 1,10-phenanthrolene) and [Ru(bpy)2TIP]2+ (2) (bpy = 2,2'-bipyridyl), are synthesized and characterized by UVVis, IR, 1H and 13C NMR, and ESI-MS spectra. Interaction of these complexes with CT-DNA is studied using UV-Vis and florescence spectra, viscosity measurements and molecular docking studies. The latter supports binding ability of complexes with stability constants deduced from UV-Vis and florescence spectra. The studies reveal that both Ru(II) polypyridyl complexes bind to DNA predominantly by intercalation, and the binding constant of complex 1 is greater than that of complex 2. Complexes 1 and 2 cleave the pBR 322 DNA under UV light.
作者简介
G. Srinivas
Department of Chemistry, University College of Science; Department of Chemistry, Government Degree College Manthani
Email: ssnsirasani@gmail.com
印度, Hyderabad, Telangana, 500007; Peddapalli District, Telangana, 505184
V. Ravi Kumar
Department of Chemistry, University College of Science
Email: ssnsirasani@gmail.com
印度, Hyderabad, Telangana, 500007
K. Laxma Reddy
Department of Chemistry, University College of Technology
Email: ssnsirasani@gmail.com
印度, Hyderabad, Telangana, 500007
Y. Praveen Kumar
Department of Chemistry
Email: ssnsirasani@gmail.com
印度, Narsapur, Medak District, Telangana
S. Satyanarayana
Department of Chemistry, University College of Science
编辑信件的主要联系方式.
Email: ssnsirasani@gmail.com
印度, Hyderabad, Telangana, 500007