Synthesis, Antioxidant, and Antimicrobial Activities of Novel Bis-Aroylbenzofuran Fused 1,2,3-Triazoles Bearing Alkane Spacers
- 作者: Kiran K.1,2, Sarasija M.1, Rao B.3, Jeyanthi A.1, Rao A.4, Ashok D.3
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隶属关系:
- Department of Chemistry
- Integrum Life Sciences Private Limited, Plot no. 34, ALEAP Industrial Estate, Pragathi Nagar, Gajularamaram, Quthubullapur Mandal, Medchal District
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Vagdevi Innoscience Pvt.Ltd, Nacharam, Hyderabad
- 期: 卷 88, 编号 11 (2018)
- 页面: 2410-2419
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222556
- DOI: https://doi.org/10.1134/S1070363218110257
- ID: 222556
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详细
A series of novel fused bis-aroylbenzodifuran derivatives linked via bis-1,2,3-triazole moiety containing alkane spacers 15, 19a–19d are synthesized in 68–80% yields by the Huisgen cycloaddition (Click) reaction of alkane azides 4–8 with acetylene intermediate 3 followed by cyclization of the corresponding bishydroxyacetophenone derivatives 9–13 with various p-substituted phenacyl bromides 14a–14d. The isolated compounds are characterized by IR, NMR and mass spectral data. The title compounds are screened in vitro for their antimicrobial and antioxidant activities. The results of the studies indicate antimicrobial activity of compounds 16a and 16b compared to that of the standard Streptomycin. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity test of the synthesized compounds indicates the compounds 15d and 16d as highly active as compared to the standard 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT).
作者简介
K. Kiran
Department of Chemistry; Integrum Life Sciences Private Limited, Plot no. 34, ALEAP Industrial Estate, Pragathi Nagar, Gajularamaram, Quthubullapur Mandal, Medchal District
Email: lionsarasija@gmail.com
印度, Telangana, 500085; Telangana, 500072
M. Sarasija
Department of Chemistry
编辑信件的主要联系方式.
Email: lionsarasija@gmail.com
印度, Telangana, 505001
B. Rao
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: lionsarasija@gmail.com
印度, Telangana, 500007
A. Jeyanthi
Department of Chemistry
Email: lionsarasija@gmail.com
印度, Telangana, 505001
A. Rao
Vagdevi Innoscience Pvt.Ltd, Nacharam, Hyderabad
Email: lionsarasija@gmail.com
印度, Telangana, 500007
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: lionsarasija@gmail.com
印度, Telangana, 500007