Synthesis of Homoleptic and Heteroleptic Ruthenium Complexes Appended with Glucosyl Ligand by the Click-to-Chelate Approach
- 作者: Xiao N.1, Cheng A.1, Zhu Q.1, Cheng Q.1, Wu R.1, Yu B.1, Wang Z.1
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隶属关系:
- School of Pharmaceutical Sciences
- 期: 卷 87, 编号 12 (2017)
- 页面: 3036-3042
- 栏目: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221847
- DOI: https://doi.org/10.1134/S1070363217120507
- ID: 221847
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详细
Homoleptic and heteroleptic complexes of Ru(TAGP-tapy)3Cl2 {TAGP-tapy is 2-[1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl]-pyridine} bearing a clustered glucose-derived ligand and Ru(bpy)2(TAGP-tapy)Cl2 (bpy is 2,2'-bipyridine) have been synthesized by the chelating reaction of RuCl3·3H2O with TAGP-tapy and cis-Ru(bpy)2Cl2 with TAGP-tapy, respectively. The bidentate 1,2,3-triazolelinked glucose-derived ligand TAGP-tapy was prepared by copper-catalyzed coupling (click reaction) of 2-ethynylpyridine with acetyl protected glucosyl azide, 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide (TAGP-N3). TAGP-N3 was prepared by nucleophilic substitution reaction of 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (TAGP-Br) with NaN3. These ruthenium complexes were purified by column chromatography or HPLC. Structures of the intermediates and ruthenium complexes were confirmed by HPLC, 1H and 13C NMR, FT-IR, and ESI-MS spectroscopies. UV-Vis and fluorescence spectroscopic methods were used to study optical properties of the ligand TAGP-tapy and ruthenium complexes. TAGP-tapy exhibited interesting solvent-polarity dependent fluorescence properties and a significant red-shift in emissions. Both complexes demonstrated distinctive fluorescence emission band in the visible region.
作者简介
N. Xiao
School of Pharmaceutical Sciences
编辑信件的主要联系方式.
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
A. Cheng
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
Q. Zhu
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
Q. Cheng
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
R. Wu
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
B. Yu
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069
Z. Wang
School of Pharmaceutical Sciences
Email: xiaonao@ccmu.edu.cn
中国, Beijing, 100069