Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives
- 作者: Anil V.1, Shankar B.1, Bharath G.2, Jalapathi P.1
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隶属关系:
- Department of Chemistry, University College of Science
- Bioengineering and Environmental Sciences Division
- 期: 卷 87, 编号 12 (2017)
- 页面: 3017-3022
- 栏目: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221832
- DOI: https://doi.org/10.1134/S1070363217120477
- ID: 221832
如何引用文章
详细
A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.
作者简介
V. Anil
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
印度, Saifabad, Hyderabad, Telangana, 500004
B. Shankar
Department of Chemistry, University College of Science
Email: pochampalli.ou.chemi@gmail.com
印度, Saifabad, Hyderabad, Telangana, 500004
G. Bharath
Bioengineering and Environmental Sciences Division
Email: pochampalli.ou.chemi@gmail.com
印度, Hyderabad, 500007
P. Jalapathi
Department of Chemistry, University College of Science
编辑信件的主要联系方式.
Email: pochampalli.ou.chemi@gmail.com
印度, Saifabad, Hyderabad, Telangana, 500004