Synthesis of some substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5 H -furo[3,2- g ]chromene-9-sulfonate derivatives as potent antihypertensive α-blocking and antiarrythmic agents

A. E. Amr; M. M. Abdalla; S. A. Essaouy; M. M. H. Areef; M. H. Elgamal; T. A. Nassear; A. E. Haschich

doi:10.1134/S1070363217080308

Synthesis of some substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]chromene-9-sulfonate derivatives as potent antihypertensive α-blocking and antiarrythmic agents

作者: Amr A.¹^,2, Abdalla M.³, Essaouy S.⁴, Areef M.⁴, Elgamal M.², Nassear T.⁴, Haschich A.⁴
隶属关系:
1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
2. Applied Organic Chemistry Department
3. Research Unit
4. Organic Chemistry Department, Faculty of Science
期: 卷 87, 编号 8 (2017)
页面: 1826-1833
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/221107
DOI: https://doi.org/10.1134/S1070363217080308
ID: 221107

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A number of substituted 4-methoxy-7-methyl-6-(substituted methyl)-5-oxo-5H-furo[3,2-g]-chromene-9-sulfonates 3a–3f and 4a–4c were synthesized. Treatment of visnagin-9-sulphonyl esters by secondary amines gave the substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]-chromene-9-sulfonates 5a–5f and 6a–6c. Some of synthesized compounds were tested as potential α-blocking and antiarrythmic agents.