2-(2-thienyl)-6-methyl-6H-imidazo[4,5-g][1,3]benzothiazole: Synthesis and some transformations
- 作者: Elchaninov M.1, Pyatnitsyna E.1
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隶属关系:
- Platov Southern Russian State Polytechnic University
- 期: 卷 87, 编号 3 (2017)
- 页面: 420-424
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/218673
- DOI: https://doi.org/10.1134/S1070363217030100
- ID: 218673
如何引用文章
详细
Oxidation of N-(1-methylbenzimidazol-5-yl)thiophene-2-carbothioamide with potassium ferricyanide in an alkaline medium by Jacobson’s method afforded 2-(thien-2-yl)-6-methyl-6H-imidazo[4,5-g][1,3]benzothiazole. The latter enters into the electrophilic substitution reaction (nitration, bromination, formylation, acylation) exclusively at the position 5 of the thiophene ring. Characteristic reactions of nucleophilic substitution occurred at the imidazole ring. Quaternization with methyl iodide in benzene furnished the corresponding quaternary salt, whereas the Chichibabin amination with an excess of sodium amide in xylene gave negative result.
作者简介
M. Elchaninov
Platov Southern Russian State Polytechnic University
编辑信件的主要联系方式.
Email: elchaninov-43@mail.ru
俄罗斯联邦, ul. Prosveshcheniya 132, Novocherkassk, 346428
E. Pyatnitsyna
Platov Southern Russian State Polytechnic University
Email: elchaninov-43@mail.ru
俄罗斯联邦, ul. Prosveshcheniya 132, Novocherkassk, 346428
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