Chemical and radiological toxicity of uranium compounds
- 作者: Gudkov S.1,2,3, Chernikov A.1, Bruskov V.1
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隶属关系:
- Institute of Theoretical and Experimental Biophysics
- Moscow Regional Research and Clinical Institute (MONIKI)
- Lobachevskii Nizhny Novgorod State University
- 期: 卷 86, 编号 6 (2016)
- 页面: 1531-1538
- 栏目: Selected articles originally published in Russian in Rossiiskii Khimicheskii Zhurnal (Russian Chemistry Journal)
- URL: https://journals.rcsi.science/1070-3632/article/view/215611
- DOI: https://doi.org/10.1134/S1070363216060517
- ID: 215611
如何引用文章
详细
Studies into the effects from environmental pollution by uranium compounds have been overviewed. Analysis of the impact of uranium oxides resulted from military operations using armor-piercing shells made of depleted uranium shows a predominance of chemical toxicity caused by the strong oxidizing power of uranyl ions. They induce oxidative stress through the generation of reactive oxygen species. As a result, oxidative damage to biomolecules and disruption of metabolic processes occur. Oxidative DNA damage causes long-term genotoxic effects in the form of mutagenesis, carcinogenesis, and other pathologies. The necessity of prohibiting the use of depleted uranium shells as chemical weapons of mass destruction has been substantiated.
作者简介
S. Gudkov
Institute of Theoretical and Experimental Biophysics; Moscow Regional Research and Clinical Institute (MONIKI); Lobachevskii Nizhny Novgorod State University
编辑信件的主要联系方式.
Email: S_makariy@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Shchepkina 61/2, Moscow, 129110; pr. Gagarina 23, Nizhny Novgorod, 603950
A. Chernikov
Institute of Theoretical and Experimental Biophysics
Email: S_makariy@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290
V. Bruskov
Institute of Theoretical and Experimental Biophysics
Email: S_makariy@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290