Synthesis, characterization, DNA binding, antibacterial, and antioxidant activity of new bis-phthalimides
- 作者: Arif R.1, Nayab P.1, Rahisuddin P.1
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隶属关系:
- Department of Chemistry
- 期: 卷 86, 编号 6 (2016)
- 页面: 1374-1380
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215346
- DOI: https://doi.org/10.1134/S1070363216060232
- ID: 215346
如何引用文章
详细
New bis-phthalimides were synthesized by 2: 1 condensation of phthalic anhydride and tetrachlorophthalic anhydride with 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, and 4-hydroxypyrimidine- 2,6-diamine. The synthesized compounds were characterized by elemental analyses and IR, 1H NMR, and mass spectra. Their interaction with calf thymus DNA (ct-DNA) was studied by UV-Vis spectrophotometry, cyclic voltammetry, and viscosity measurements, which revealed intercalative mode of binding to ct-DNA. Antibacterial activity of the synthesized compounds against Escherichia coli and Streptococcus mutans was assessed in vitro by the agar well diffusion method. The antioxidant activity of these compounds was estimated by DPPH assay.
作者简介
R. Arif
Department of Chemistry
Email: rahisuddin@jmi.ac.in
印度, New Delhi, 110025
P. Nayab
Department of Chemistry
Email: rahisuddin@jmi.ac.in
印度, New Delhi, 110025
P. Rahisuddin
Department of Chemistry
编辑信件的主要联系方式.
Email: rahisuddin@jmi.ac.in
印度, New Delhi, 110025