An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids
- Авторы: Wang X.1, Liu J.2, Zhang Y.1
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Учреждения:
- College of Biology Pharmacy and Food Engineering
- Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science
- Выпуск: Том 88, № 5 (2018)
- Страницы: 1036-1041
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222216
- DOI: https://doi.org/10.1134/S1070363218050328
- ID: 222216
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Аннотация
A number of 4'-substituted (R = H, Me, Cl, F) flavone derivatives is synthesized from 2-hydroxyacetophenones using the modified Baker–Venkataraman reaction. Compound [3-(4-fluorobenzoyl)-5- hydroxy-4'-fluoroflavone] was synthesized for the first time with the yield of 12%. Antiproliferative assays indicate that the synthesized flavones with F substituent at the 4' position demonstrate higher activity than the other flavone derivatives, particularly against HeLa and MCF-7 with the IC50 9.5 and 2.7 μM, respectively.
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Об авторах
X. Wang
College of Biology Pharmacy and Food Engineering
Автор, ответственный за переписку.
Email: xuejunwangd@163.com
Китай, Shangluo, 726000
J. Liu
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science
Email: xuejunwangd@163.com
Китай, Xi’an, 710069
Y. Zhang
College of Biology Pharmacy and Food Engineering
Email: xuejunwangd@163.com
Китай, Shangluo, 726000