Synthesis of some new thiazole derivatives and their cytotoxicity on different human tumor cell lines
- Авторы: Mohamed A.1,2, Abdel-Hafez N.2, Kassem A.3, Abbas E.3, Mounier M.4
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Учреждения:
- Chemistry Department, College of Science
- Applied Organic Chemistry Department
- Department of Chemistry of Natural and Microbial Products
- Pharmacognosy Department, Drug Bioassay-Cell Culture Laboratory, Pharmaceutical and Drug Industries Division
- Выпуск: Том 87, № 10 (2017)
- Страницы: 2391-2400
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221450
- DOI: https://doi.org/10.1134/S1070363217100218
- ID: 221450
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Аннотация
Some novel 1-(inden-3-ylidene)-2-(thiazol-2-ylidene)hydrazine derivatives 3–9 were synthesized by the Hantzsch reaction of thiosemicarbazone derivatives 2a–2c with halo ketones and halo esters. Thiosemicarbazone derivatives reacted with hydrozonyl chlorides to give diazenyl-4-methylthiazole derivatives 11a–11d. Structures of the products were elucidated from IR, 1H, and 13C NMR, and Mass spectra elucidate. The synthesized compounds were screened for their cytotoxicity against three human tumor cell lines. Twenty compounds showed high (≥60 %) antiproliferative activity over breast cancer (MCF-7). Compounds 2b, 3c, 4a, 4b, 6b, 6c, 7b, 8a, and 11b possessed higher cytotoxic activity over breast tumor cell line than Doxorubicin.
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Об авторах
A. Mohamed
Chemistry Department, College of Science; Applied Organic Chemistry Department
Автор, ответственный за переписку.
Email: ammewas1@gmail.com
Саудовская Аравия, Sakaka, Al-Jouf, 72341; Dokki, Cairo, 12622
N. Abdel-Hafez
Applied Organic Chemistry Department
Email: ammewas1@gmail.com
Египет, Dokki, Cairo, 12622
A. Kassem
Department of Chemistry of Natural and Microbial Products
Email: ammewas1@gmail.com
Египет, Dokki, Cairo
E. Abbas
Department of Chemistry of Natural and Microbial Products
Email: ammewas1@gmail.com
Египет, Dokki, Cairo
M. Mounier
Pharmacognosy Department, Drug Bioassay-Cell Culture Laboratory, Pharmaceutical and Drug Industries Division
Email: ammewas1@gmail.com
Египет, Dokki, Cairo