Отправить статью по E-mail Synthesis, crystal structure, antibacterial, cytotoxic, and anticancer activities of new Pd(II) complexes of tri-p-tolyl phosphine with thiones
- Авторы: Aziz I.1, Sirajuddin M.1, Nadeem S.1, Tirmizi S.1, Khan Z.1, Munir A.1, Ullah K.1, Farooqi B.2, Khan H.1, Tahir M.3
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Учреждения:
- Department of Chemistry
- Institute of Chemistry
- Department of Physics
- Выпуск: Том 87, № 9 (2017)
- Страницы: 2073-2082
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221280
- DOI: https://doi.org/10.1134/S1070363217090249
- ID: 221280
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Аннотация
Four Pd(II) complexes of general formula [Pd(L1)2(L2)2], where L1 = pyridine-2(1H)-thione, pyrimidine-2(1H)-thione, pyridine-4(1H)-thione, and pyridine-4(1H)-thione, L2 = tri-p-tolylphosphine, have been synthesized by direct reaction of K2[PdCl4] with phosphine and heterocyclic thiones ligands in 1 : 2 : 2 molar ratio. The complexes have been characterized by elemental analyses, FT-IR and multinuclear NMR spectroscopy. The complexes 1 and 2 were also characterized by single crystal X-ray diffraction which revealed that the Pd(II) atom adopted a nearly square planar geometry with two tri-p-tolyphosphine molecules bound in a trans fashion and also two pyridine-2(1H)-thione (1) or pyrimidine-2(1H)-thione (2) molecules trans to each other. The compounds were tested for antibacterial activity, DNA interaction by brine shrimp lethality bioassay, antitumor activity, and gel electrophoresis. The complexes demonstrated moderate activity against gram positive and gram negative bacterial strains in comparison with a standard drug imipenum. Their antitumor activity against MCF7 tumor cell line was determined to be comparable to that of doxorubicin. The investigated compounds demonstrated no cytotoxic effect in brine shrimp bioassay study.
Об авторах
I. Aziz
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
M. Sirajuddin
Department of Chemistry
Автор, ответственный за переписку.
Email: m.siraj09@gmail.com
Пакистан, Bannu
S. Nadeem
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
S. Tirmizi
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
Z. Khan
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
A. Munir
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
K. Ullah
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Islamabad, 45320
B. Farooqi
Institute of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Lahore, 54590
H. Khan
Department of Chemistry
Email: m.siraj09@gmail.com
Пакистан, Bannu
M. Tahir
Department of Physics
Email: m.siraj09@gmail.com
Пакистан, Sargodha
