Synthesis, spectroscopic, theoretical study, and biological activities of vanadium(IV) and vanadium(V) complexes with isonipecotic acid
- Авторы: Jabeen M.1, Ali S.1, Shahzadi S.1, Shahid M.2, Sharma S.3, Qanungo K.3
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Учреждения:
- Department of Chemistry
- Department of Chemistry and Biochemistry
- Department of Applied Sciences and Humanities, Faculty of Engineering and Technology
- Выпуск: Том 87, № 3 (2017)
- Страницы: 530-538
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/218905
- DOI: https://doi.org/10.1134/S1070363217030240
- ID: 218905
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Аннотация
Vanadium(IV) and vanadium(V) complexes 1–7 have been synthesized by the reaction of isonipecotic acid with VOSO4 · 3 H2O, VCl3(THF)3, and NH4VO3 at different metal/ligand ratios under stirring/ reflux conditions. The synthesized complexes have been characterized by elemental analyses and UV/Vis and FT-IR spectra. The FT-IR spectroscopic data suggest bidentate nature of the ligand, which is also confirmed by semiempirical study. Electrostatic surface potential (ESP) map shows that the coordinating oxygen atoms in complex 1 have more negative charges than the V=O oxygen atom. The dipole moment vectors of the optimized structures of complexes 1 and 5 are not aligned along the V=O bond due to the lack of symmetry. DNA binding study of complexes 1–7 showed that increase of the DNA concentration is accompanied by considerable decrease of the absorbance and by a 1–4-nm blue shift of the absorption maximum, indicating intercalative binding mode of the complexes to the DNA base pairs. In vitro DNA damage protection assay showed that complexes 1 and 3 exhibited plasmid DNA protection by scavenging oxidation products.
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Об авторах
M. Jabeen
Department of Chemistry
Email: drsa54@hotmail.com
Пакистан, Faisalabad
S. Ali
Department of Chemistry
Автор, ответственный за переписку.
Email: drsa54@hotmail.com
Пакистан, Islamabad, 45320
S. Shahzadi
Department of Chemistry
Email: drsa54@hotmail.com
Пакистан, Islamabad, 45320
M. Shahid
Department of Chemistry and Biochemistry
Email: drsa54@hotmail.com
Пакистан, Faisalabad
S. Sharma
Department of Applied Sciences and Humanities, Faculty of Engineering and Technology
Email: drsa54@hotmail.com
Индия, Sikar, Rajasthan, 332311
K. Qanungo
Department of Applied Sciences and Humanities, Faculty of Engineering and Technology
Email: drsa54@hotmail.com
Индия, Sikar, Rajasthan, 332311