Alkylation, amino(hydroxy)methylation, and cyanoethylation of 5-substituted 4-phenyl-4H-1,2,4-triazole-3-thiols
- Авторы: Kaldrikyan M.1, Minasyan N.1, Melik-Ogandzanyan R.1
-
Учреждения:
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Выпуск: Том 86, № 2 (2016)
- Страницы: 305-311
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213755
- DOI: https://doi.org/10.1134/S1070363216020171
- ID: 213755
Цитировать
Аннотация
Reactions of 1,2,4-triazole-3-thiols with 2-bromopropionic acid, 2-bromocaproic acid, ethylene chlorohydrine, chloroacetamide, 3-bromo-4-methoxybenzyl chloride, 2-methoxy-5-acetylbenzyl chloride, and 2-(2-chlorophenoxy)ethyl chloride in the presence of KOH have afforded new 3-sulfanyl-1,2,4-triazoles in high yields. Aminomethylation of 1,2,4-triazole-3-thiols in the presence of formaldehyde has given the corresponding 2-aminomethyl-2H-1,2,4-triazole-3(4H)-thiones. Interaction of triazole-3-thiols with formalin and acrylonitrile has resulted in the formation of N2-hydroxymethyl- and 3-(2-cyanoethyl)sulfanyl derivatives.
Об авторах
M. Kaldrikyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: nunemin@gmail.com
Армения, Yerevan
N. Minasyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Автор, ответственный за переписку.
Email: nunemin@gmail.com
Армения, ave. Azatutyan 26, Yerevan, 0014
R. Melik-Ogandzanyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: nunemin@gmail.com
Армения, Yerevan