Chemical Transformations of Chlorophyll a and Possible Areas for Application of Its Derivatives

Resumo

Chemical transformations of chlorophyll a, aimed to develop photosensitizers for the antimicrobial and anticancer therapy, as well as for boron neutron capture therapy, have been considered. Research works on the development of purpurine 18 and its analogues have been presented; derivatives with intensive absorption in the near-infrared region of the spectrum, looking promising for photodynamic anticancer therapy, have been synthesized. A large series of works on the synthesis of N-hydroxy and N-amino cycloimides of chlorin p₆ have been carried out. Carbohydrate derivatives of chlorin, containing the indicated fragments in various positions of the macrocycle, have been synthesized. The synthesis of chlorin conjugates with the closo-decaborate fragment and bis-dicarbollide of cobalt has been performed. The methods of 1,3-dipolar cycloaddition and the Sonogashira reaction have been used to obtain these conjugates. Chlorin-fullerene conjugates, including water-soluble derivatives, have been synthesized and their spectral and other physicochemical properties have been studied.