Synthesis of Isomeric Aminomethyl Derivatives of Furylmethanephosphonates
- Autores: Pevzner L.1
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Afiliações:
- St. Petersburg State Institute of Technology (Technical University)
- Edição: Volume 88, Nº 10 (2018)
- Páginas: 2072-2078
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222469
- DOI: https://doi.org/10.1134/S1070363218100079
- ID: 222469
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Resumo
By chloromethylation of diethyl 2- and 3-furylmethanephosphonates 5-chloromethylfur-2(3)-ylmethanephosphonates were synthesized. The other four isomers of chloromethyl derivatives of furylmethanephosphonates were prepared by substitution of hydroxy groups in the corresponding phosphorylated furylmethanols via the reaction with thionyl chloride in the presence of pyridine. Thermal stability of these chlorides was sufficiently high, and they were involved in nucleophilic substitution of chlorine with azido group by treating with sodium azide in boiling acetonitrile in the presence of potassium iodide. No decomposition of substrates was observed. The azides obtained were reduced to amines with triphenylphosphine in ethanol.
Sobre autores
L. Pevzner
St. Petersburg State Institute of Technology (Technical University)
Autor responsável pela correspondência
Email: pevzner_lm@list.ru
Rússia, Moskovskii pr. 26, St. Petersburg, 190031