Influence of Oxidation Conditions on the Yield of 2-Substituted Imidazole-4,5-dicarboxylic Acids
- Autores: Brusina M.1,2, Gubina Y.2, Nikolaev D.2, Ramsh S.2, Piotrovskii L.1
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Afiliações:
- Institute of Experimental Medicine
- St. Petersburg State Technological Institute (Technical University)
- Edição: Volume 88, Nº 5 (2018)
- Páginas: 874-878
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222172
- DOI: https://doi.org/10.1134/S1070363218050055
- ID: 222172
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Resumo
Conditions were found which allow 2-alkyl-substituted imidazole-4,5-dicarboxylic acids to be synthesized in preparative quantities by the oxidation of 2-alkylbenzimidazoles with hydrogen peroxide. It was shown that optimal results can be obtained at the concentration of 2-alkylimidazole in sulfuric acid of 1 M and the hydrogen peroxide: 2-alkylbenzimidazole molar ratio of 11: 1. Oxidation under these conditions results in higher yields of the target 2-alkylimidazole-4,5-dicarboxylic acids, including those with a branched alkyl group.
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Sobre autores
M. Brusina
Institute of Experimental Medicine; St. Petersburg State Technological Institute (Technical University)
Autor responsável pela correspondência
Email: mashasemen@gmail.com
Rússia, St. Petersburg; Moskovskii pr. 26, St. Petersburg, 190013
Yu. Gubina
St. Petersburg State Technological Institute (Technical University)
Email: mashasemen@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
D. Nikolaev
St. Petersburg State Technological Institute (Technical University)
Email: mashasemen@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
S. Ramsh
St. Petersburg State Technological Institute (Technical University)
Email: mashasemen@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
L. Piotrovskii
Institute of Experimental Medicine
Email: mashasemen@gmail.com
Rússia, St. Petersburg