Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic  C -Nucleoside Analogues

H. A. Soliman; E. R. Kotb; M. N. El-Bayaa; O. M. Kutkat; F. M. E. Abdel-Magied

doi:10.1134/S1070363218040291

Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

Autores: Soliman H.¹, Kotb E.¹, El-Bayaa M.¹, Kutkat O.², Abdel-Magied F.¹
Afiliações:
1. Photochemistry Department
2. Environmental Research Division
Edição: Volume 88, Nº 4 (2018)
Páginas: 815-824
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222157
DOI: https://doi.org/10.1134/S1070363218040291
ID: 222157

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Resumo

New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C-nucleosides, were synthesized. Novel O-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a, 9a, and 14 demonstrated high inhibition activity.