Synthesis, Characterization, DNA Interaction Study, Antibacterial and Anticancer Activities of New Palladium(II) Phosphine Complexes
- Autores: Aziz I.1, Sirajuddin M.1, Munir A.1, Tirmizi S.1, Nadeem S.1, Tahir M.2, Sajjad W.3
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Afiliações:
- Department of Chemistry
- Department of Physics
- Department of Microbiology, Faculty of Biological Sciences
- Edição: Volume 88, Nº 3 (2018)
- Páginas: 551-559
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222082
- DOI: https://doi.org/10.1134/S1070363218030258
- ID: 222082
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Resumo
A series of palladium(II) complexes with N,N-dimethylthiourea and phosphines [tri-p-tolylphosphine (Tptp), benzyl(diphenyl)phosphine (Bdp), cyclohexyl(diphenyl)phosphine (Cdp)] were synthesized by the direct reaction of K2[(PdCl4)] with the corresponding phosphines and then with N,N-dimethylthiourea at a molar ratio of 1: 2: 2. The general formula of these complexes is [Pd(L1)2(L2)2]Cl2, where L1 = N,N-dimethylthiourea (Dmtu), L2 = Tptp, Bdp, Cdp. The complexes were characterized by elemental analyses, multinuclear NMR (1H, 13C, 31P), and FT-IR. The complex with cyclohexyl(diphenyl)phosphine was also characterized by single crystal X-ray analysis. The spectral and crystallographic data suggest monodentate coordination of dimethylthiourea through the sulfur atom and of the phosphine ligand through the phosphorus atom and distorted square planar environment of palladium(II). The synthesized complexes have been screened for DNAbinding, antibacterial, cytotoxic, and antitumor activities. The complexes show interaction with DNA via intercalative mode. The complexes show good activity against both gram positive and gram negative bacteria as compared to that of a standard drug, Imipenem. Their antitumor activity against MCF7 tumor cell line was found to be comparable with doxorubicin. MTT assay was used to investigate the cytotoxicity of the studied compounds having activity order: 3 > 2 > 1.
Sobre autores
I. Aziz
Department of Chemistry
Email: m.siraj09@yahoo.com
Paquistão, Islamabad, 45320
M. Sirajuddin
Department of Chemistry
Autor responsável pela correspondência
Email: m.siraj09@yahoo.com
Paquistão, Bannu, KPK, 28100
A. Munir
Department of Chemistry; Department of Chemistry
Email: m.siraj09@yahoo.com
Paquistão, Islamabad, 45320; Lahore
S. Tirmizi
Department of Chemistry
Email: m.siraj09@yahoo.com
Paquistão, Islamabad, 45320
S. Nadeem
Department of Chemistry
Email: m.siraj09@yahoo.com
Paquistão, Islamabad, 45320
M. Tahir
Department of Physics
Email: m.siraj09@yahoo.com
Paquistão, Sargodha
W. Sajjad
Department of Microbiology, Faculty of Biological Sciences
Email: m.siraj09@yahoo.com
Paquistão, Islamabad, 45320