Synthesis and antimicrobial activity of novel substituted 4-[3-(1H-benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol derivatives
- Autores: Anil V.1, Shankar B.1, Bharath G.2, Jalapathi P.1
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Afiliações:
- Department of Chemistry
- Bioengineering and Environmental Sciences Division
- Edição: Volume 87, Nº 11 (2017)
- Páginas: 2648-2653
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221603
- DOI: https://doi.org/10.1134/S1070363217110202
- ID: 221603
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Resumo
A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis. Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.
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Sobre autores
V. Anil
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
B. Shankar
Department of Chemistry
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004
G. Bharath
Bioengineering and Environmental Sciences Division
Email: pochampalli.ou.chemi@gmail.com
Índia, Hyderabad, 500007
P. Jalapathi
Department of Chemistry
Autor responsável pela correspondência
Email: pochampalli.ou.chemi@gmail.com
Índia, Saifabad, Hyderabad, Telangana, 500004