Synthesis and antimicrobial activity of fused isatin and diazepine derivatives derived from 2-acetyl benzofuran
- Autores: Kenchappa R.1, Bodke Y.1, Telkar S.2, Nagaraja O.1
-
Afiliações:
- Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
- Department of Post-Graduate Studies and Research in Biotechnology, Jnana Sahyadri
- Edição: Volume 87, Nº 9 (2017)
- Páginas: 2027-2038
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221251
- DOI: https://doi.org/10.1134/S1070363217090195
- ID: 221251
Citar
Resumo
Acetyl benzofurans 1a, 1b reacted with isatins 2a–2f in the presence of pyridine to give corresponding 3-[2-(1-benzofuran-2-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one derivatives 3a–3l. Dehydration of the latter in acidic media led to the corresponding α,β-unsaturated ketones 4a–4l. The structures of newly synthesized compounds 3a–3l and 4a–4l were established on the basis of analytical and spectral data. The synthesized compounds were screened for their antibacterial and antifungal activities. Compounds 5d, 5f, and 5h displayed excellent antimicrobial activity. The synthesized compounds were studied for docking on the enzyme, Glucosamine-6-phosphate Synthase.
Palavras-chave
Sobre autores
R. Kenchappa
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
Email: ydbodke@gmail.com
Índia, Shankaraghatta, Shivamogga, Karnataka, 577451
Y. Bodke
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
Autor responsável pela correspondência
Email: ydbodke@gmail.com
Índia, Shankaraghatta, Shivamogga, Karnataka, 577451
S. Telkar
Department of Post-Graduate Studies and Research in Biotechnology, Jnana Sahyadri
Email: ydbodke@gmail.com
Índia, Shankaraghatta, Shivamogga, Karnataka, 577451
O. Nagaraja
Department of Post-Graduate Studies and Research in Industrial Chemistry, Jnana Sahyadri
Email: ydbodke@gmail.com
Índia, Shankaraghatta, Shivamogga, Karnataka, 577451