Synthesis and study of basic hydrolysis of novel derivatives of  N -[(adamantan-1-yl)methyl]aniline

I. A. Novakov; A. S. Babushkin; A. A. Vernigora; I. A. Kirillov; M. B. Navrotskii; B. S. Orlinson; S. N. Voloboev

doi:10.1134/S1070363216120057

Synthesis and study of basic hydrolysis of novel derivatives of N-[(adamantan-1-yl)methyl]aniline

Autores: Novakov I.¹, Babushkin A.¹, Vernigora A.¹, Kirillov I.¹, Navrotskii M.¹, Orlinson B.¹, Voloboev S.²
Afiliações:
1. Volgograd State Technical University
2. LUKOIL-Volgogradneftepererabotka
Edição: Volume 86, Nº 12 (2016)
Páginas: 2599-2605
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/216665
DOI: https://doi.org/10.1134/S1070363216120057
ID: 216665

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Resumo

Using the Leuckart–Wallach reaction, novel conformationally flexible structural analogs of Bromantane drug have been synthesized from 3-haloadamantane-1-carbaldehydes. Basic hydrolysis of the prepared compounds has been studied as a model of one of the pathways of their transformations in vivo.