Synthesis, Antimicrobial Activity, and Docking Studies of 2-Mercapto Substituted Quinazolin-4(3 H )-one and Their Derivatives

P. Balaswamy; S. Aravind; S. Purushotham Reddy; B. Satyanarayana

doi:10.1134/S1070363218040230

Synthesis, Antimicrobial Activity, and Docking Studies of 2-Mercapto Substituted Quinazolin-4(3H)-one and Their Derivatives

Авторлар: Balaswamy P.¹, Aravind S.¹, Purushotham Reddy S.¹, Satyanarayana B.¹
Мекемелер:
1. Department of Chemistry
Шығарылым: Том 88, № 4 (2018)
Беттер: 774-779
Бөлім: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222147
DOI: https://doi.org/10.1134/S1070363218040230
ID: 222147

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Аннотация

An efficient, eco-friendly synthesis of a series of 2-{[3-oxo-3-(alkyl/aryl-1-yl)alkyl]thio}-3-substituted quinazolin-4(3H)-ones employing quinazolin-4(3H)-one and corresponding halo-acyl/haloalkyl as electrophiles is presented. The products were assayed for anti-bacterial activity on four bacterial species (Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus). In-silico molecular docking studies were carried out.