Octahedral titanium(IV) complexes with five novel hydroximic acid ligands: Synthesis, spectroscopic characterization, and in vitro activities on IMR-32 and CHO cell lines and ten bacterial strains
- Authors: Sheetal 1, Nehra K.2, Kaushal R.3, Arora S.4, Kaur D.4, Kaushal R.1
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Affiliations:
- Department of Chemistry
- Department of Biotechnology
- Department of Parasitology
- Department of Botanical and Environmental Sciences
- Issue: Vol 86, No 1 (2016)
- Pages: 154-160
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213522
- DOI: https://doi.org/10.1134/S1070363216010242
- ID: 213522
Cite item
Abstract
Complexes with the composition TiCl4L2 where L = benzohydroxamic acid, 2-hydroxybenzo-hydroxamic acid, acetohydroxamic acid, hydroxyurea, and N-hydroxy-N-phenylbenzamide have been synthesized by reaction of titanium tetrachloride with 2 equiv of the corresponding hydroxamic acids. The structure of these complexes has been studied by analytical and spectroscopic (FT-IR, UV-Vis, MS, 1H and 13C NMR) techniques. The free ligands and the complexes have been tested in vitro to evaluate their activities against IMR-32 (neuroblastoma) cancer cell line, CHO p-40 (Chinese hamster ovary) normal cells, and ten pathogenic bacterial strains.
About the authors
Sheetal
Department of Chemistry
Email: kaushalraj384@gmail.com
India, Hamirpur, Himachal Pradesh, 177005
K. Nehra
Department of Biotechnology
Email: kaushalraj384@gmail.com
India, Murthal, Sonepat (Haryana), 131039
R. Kaushal
Department of Parasitology
Author for correspondence.
Email: kaushalraj384@gmail.com
India, Chandigarh, 160012
S. Arora
Department of Botanical and Environmental Sciences
Email: kaushalraj384@gmail.com
India, Amritsar, Punjab, 143005
D. Kaur
Department of Botanical and Environmental Sciences
Email: kaushalraj384@gmail.com
India, Amritsar, Punjab, 143005
R. Kaushal
Department of Chemistry
Email: kaushalraj384@gmail.com
India, Hamirpur, Himachal Pradesh, 177005