Synthesis and Properties of New Fluorine-Containing Thieno[2,3-b]pyridine Derivatives
- Authors: Buryi D.S.1, Dotsenko V.V.1,2, Aksenov N.A.2, Aksenova I.V.2
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Affiliations:
- Kuban State University
- North Caucasian Federal University
- Issue: Vol 89, No 9 (2019)
- Pages: 1744-1751
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223061
- DOI: https://doi.org/10.1134/S1070363219090032
- ID: 223061
Cite item
Abstract
Cyanothioacetamide reacted with 1,1,5,5-tetrafluoroacetylacetone to give 4,6-bis(difluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile, and alkylation of the latter with α-chloroacetamides afforded 3-amino-4,6-bis(difluoromethyl)thieno[2,3-b]pyridine-2-carboxamides. The structure of the key compounds was proved using two-dimensional NMR techniques. In silico analysis of potential biological activity and bioavailability of the synthesized compounds was performed.
About the authors
D. S. Buryi
Kuban State University
Email: victor_dotsenko_@mail.ru
Russian Federation, Krasnodar, 350040
V. V. Dotsenko
Kuban State University; North Caucasian Federal University
Author for correspondence.
Email: victor_dotsenko_@mail.ru
Russian Federation, Krasnodar, 350040; Stavropol
N. A. Aksenov
North Caucasian Federal University
Email: victor_dotsenko_@mail.ru
Russian Federation, Stavropol
I. V. Aksenova
North Caucasian Federal University
Email: victor_dotsenko_@mail.ru
Russian Federation, Stavropol