Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

A. I. Khlebnikov; T. M. Seilkhanov; A. E. Arinova; M. B. Isabaeva; O. A. Nurkenov; M. K. Ibraev; I. A. Schepetkin

doi:10.1134/S1070363219070028

Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

Authors: Khlebnikov A.I.¹^,2, Seilkhanov T.M.³, Arinova A.E.⁴, Isabaeva M.B.⁵, Nurkenov O.A.⁵^,4, Ibraev M.K.⁵, Schepetkin I.A.⁶^,1
Affiliations:
1. N. Kizhner Center
2. I.I. Polzunov Altai State Technical University
3. Sh. Ualikhanov Kokshetau State University
4. Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan
5. Karaganda State Technical University
6. Department of Immunology and Infectious Diseases
Issue: Vol 89, No 7 (2019)
Pages: 1360-1367
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222978
DOI: https://doi.org/10.1134/S1070363219070028
ID: 222978

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Abstract

Functionally substituted chalcones, pyrazolines, and flavonones have been synthesized. Their structure has been studied by means of ¹H and ¹³C NMR spectroscopy, including COSY and HMQC experiments. Anti-inflammatory activity of the synthesized chalcones, pyrazolines, and flavonones has been evaluated.