Three-Component Reaction of Dimedone with Aromatic Aldehydes and 5-Aminotetrazole

V. L. Gein; A. N. Prudnikova; A. A. Kurbatova; M. V. Dmitriev; V. V. Novikova; I. P. Rudakova; A. L. Starikov

doi:10.1134/S1070363219050049

Three-Component Reaction of Dimedone with Aromatic Aldehydes and 5-Aminotetrazole

Authors: Gein V.L.¹, Prudnikova A.N.¹, Kurbatova A.A.¹, Dmitriev M.V.², Novikova V.V.¹, Rudakova I.P.¹, Starikov A.L.¹
Affiliations:
1. Perm State Pharmaceutical Academy
2. Perm State National Research University
Issue: Vol 89, No 5 (2019)
Pages: 881-885
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222893
DOI: https://doi.org/10.1134/S1070363219050049
ID: 222893

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Abstract

Reactions of dimedone with aromatic aldehyde and 5-aminotetrazole monohydrate proceeded with the formation of 9-aryl-6,6-dimethyl-5,6,7,9-tetrahydrotetrazolo[5,1-b]quinazoline-8(4H)-ones or 9-aryl-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-diones depending on the nature of substituent in aromatic aldehyde. Antimicrobial, antifungal and analgesic activities of the synthesized compounds were studied.