Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles
- Authors: Shehta W.1, Abdel Hamid A.M.1
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Affiliations:
- Department of Chemistry, Faculty of Science
- Issue: Vol 89, No 4 (2019)
- Pages: 806-812
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222876
- DOI: https://doi.org/10.1134/S1070363219040273
- ID: 222876
Cite item
Abstract
Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
About the authors
W. Shehta
Department of Chemistry, Faculty of Science
Email: atefmohamed40@yahoo.com
Egypt, Zagazig, 44519
A. M. Abdel Hamid
Department of Chemistry, Faculty of Science
Author for correspondence.
Email: atefmohamed40@yahoo.com
Egypt, Zagazig, 44519