Synthesis of New Thiazolo[3,2-b][1,2,4]triazole Derivatives and Preliminary Evaluation of Their Biological Activity
- Authors: Yengoyan A.P.1,2, Pivazyan V.A.2, Chazaryan E.A.2, Hakobyan R.S.2
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Affiliations:
- Russian-Armenian University
- Pesticide Synthesis and Plant Protection Laboratory
- Issue: Vol 89, No 1 (2019)
- Pages: 32-36
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222695
- DOI: https://doi.org/10.1134/S1070363219010067
- ID: 222695
Cite item
Abstract
Heterocyclization of 3-[(1H-1,2,4-triazol-3-yl)thio]pentane-2,4-dione afforded 1-(6-methylthiazolo[3,2-b][1,2,4]-triazol-5-yl)ethan-1-one, the reactions of which with hydroxylamine, hydrazincarboxamide, hydrazincarbothioamide, hydrazine hydrate and para-toluenesulfonyl hydrazide resulted in the formation of the corresponding derivatives. 1-(6-Methylthiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one oxime reacted with alkyl halides and phenyl isocyanate to produce the corresponding O-alkyl- and O-phenylcarbamoyl derivatives. The growth regulating activity of the compounds obtained was studied.
About the authors
A. P. Yengoyan
Russian-Armenian University; Pesticide Synthesis and Plant Protection Laboratory
Author for correspondence.
Email: ayengoyan@mail.ru
Armenia, ul. H. Emina 123, Yerevan, 0051; Yerevan
V. A. Pivazyan
Pesticide Synthesis and Plant Protection Laboratory
Email: ayengoyan@mail.ru
Armenia, Yerevan
E. A. Chazaryan
Pesticide Synthesis and Plant Protection Laboratory
Email: ayengoyan@mail.ru
Armenia, Yerevan
R. S. Hakobyan
Pesticide Synthesis and Plant Protection Laboratory
Email: ayengoyan@mail.ru
Armenia, Yerevan