Facile Catalyst-Free Synthesis of New Functionalized 1H-Pyrazolo[1,2-b]phthalazines
- Authors: Elmi-Mehr M.1, Davoodnia A.1, Pordel M.1
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Affiliations:
- Department of Chemistry, Mashhad Branch
- Issue: Vol 88, No 12 (2018)
- Pages: 2595-2600
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222600
- DOI: https://doi.org/10.1134/S1070363218120216
- ID: 222600
Cite item
Abstract
Some new derivatives of 3-amino-1-aryl-N-butyl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]- phthalazine-2-carboxamide are synthesized via in situ Knoevenagel condensation of aromatic aldehydes with N-butyl-2-cyanoacetamide, which leads to 3-aryl-N-butyl-2-cyanoacrylamides. This is followed by the reaction with phthalhydrazide upon refluxing in ethanol under catalyst-free conditions. The products are characterized on the basis of IR, 1H and 13C NMR spectral data.
About the authors
M. Elmi-Mehr
Department of Chemistry, Mashhad Branch
Email: adavoodnia@mshdiau.ac.ir
Iran, Islamic Republic of, Mashhad, 91756 87119
A. Davoodnia
Department of Chemistry, Mashhad Branch
Author for correspondence.
Email: adavoodnia@mshdiau.ac.ir
Iran, Islamic Republic of, Mashhad, 91756 87119
M. Pordel
Department of Chemistry, Mashhad Branch
Email: adavoodnia@mshdiau.ac.ir
Iran, Islamic Republic of, Mashhad, 91756 87119