Synthesis, Characterization, and Antimicrobial Activity of a Series of 2-(5-Phenyl-1,3,4-oxadiazol-2-yl)-N-[(1-aryl-1H-1,2,3-triazol-4-yl)methyl]anilines Using Click Chemistry
- Authors: Venkatagiri N.1, Krishna T.1, Thirupathi P.1, Bhavani K.1, Reddy C.K.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 88, No 7 (2018)
- Pages: 1488-1494
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222330
- DOI: https://doi.org/10.1134/S1070363218070228
- ID: 222330
Cite item
Abstract
series of new triazolyl derived 1,3,4-oxadiazoles 7a–7l is synthesized with high yields by coppercatalyzed alkyne–azide cycloaddition reaction between a variety of substituted aryl/alkyl azides and 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline. Structures of intermediates and the final compounds are confirmed by FTIR, 1H and 13C NMR, and Mass spectra. The synthesized compounds demonstrate moderate antibacterial activity and potent antifungal activity against the tested strains.
About the authors
N. Venkatagiri
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, Telangana, 500007
T. Krishna
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, Telangana, 500007
P. Thirupathi
Department of Chemistry
Email: krreddych@gmail.com
India, Secunderabad, Telangana, 500010
K. Bhavani
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, Telangana, 500007
C. K. Reddy
Department of Chemistry
Author for correspondence.
Email: krreddych@gmail.com
India, Hyderabad, Telangana, 500007