Synthesis of N-Tosylates of 4-Methoxy-1,2,3,4-tetrahydrocarbazole and 2-(6-Methoxy-1-cycloalken-1-yl)anilines
- Authors: Kirillova I.А.1, Zalimova М.M.1, Mulyukova R.V.2, Vakhitova Y.V.2, Khusnitdinov R.N.3, Gataullin R.R.3
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Affiliations:
- Bashkir State University
- Institute of Biochemistry and Genetics, Ufa Scientific Center
- Institute of Organic Chemistry
- Issue: Vol 88, No 3 (2018)
- Pages: 418-424
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222046
- DOI: https://doi.org/10.1134/S1070363218030076
- ID: 222046
Cite item
Abstract
The reaction of N-tosylates of 2-(1-cycloalken-1-yl)anilines and 2,3,9a,9-tetrahydro-1H-carbazole with methanol in the presence of CuBr2 proceeds with high regioselectivity leading to the corresponding tosylates of 2-(6-methoxy-1-cycloalken-1-yl)anilines and 4-methoxy-1,2,3,4-tetrahydrocarbazole. The latter as well as N-mesyl-1,2,3,4-tetrahydrocarbazole showed moderate cytotoxic activity with respect to HEK293 cell line.
About the authors
I. А. Kirillova
Bashkir State University
Email: gataullin@anrb.ru
Russian Federation, Ufa
М. M. Zalimova
Bashkir State University
Email: gataullin@anrb.ru
Russian Federation, Ufa
R. V. Mulyukova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: gataullin@anrb.ru
Russian Federation, Ufa
Yu. V. Vakhitova
Institute of Biochemistry and Genetics, Ufa Scientific Center
Email: gataullin@anrb.ru
Russian Federation, Ufa
R. N. Khusnitdinov
Institute of Organic Chemistry
Email: gataullin@anrb.ru
Russian Federation, pr. Oktyabrya 71, Ufa, 450054
R. R. Gataullin
Institute of Organic Chemistry
Author for correspondence.
Email: gataullin@anrb.ru
Russian Federation, pr. Oktyabrya 71, Ufa, 450054