Synthesis and reactions of some novel 1-(2,7-dimethyl-1,8-naphthyridin-4-yl)hydrazine candidates


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Abstract

A series of novel 1,8-naphthyridine derivatives containing Schiff bases and amino substituents were synthesized starting from the reaction of 4-hydrazinyl-2,7-dimethyl-1,8-naphthyridine with different active carbonyl groups, acid monoanhydrides and tetracarboxylic acid anhydrides. Structures of new compounds were elucidated by means of physical and spectroscopic analyses.

About the authors

N. M. Khalifa

Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy; Therapeutically Chemistry Department, Pharmaceutical and Drug Industries Division

Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622

M. A. Al-Omar

Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy

Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451

N. S. Ahmed

Therapeutically Chemistry Department, Pharmaceutical and Drug Industries Division; Chemistry Department, Faculty of Science

Email: nagykhalifa@hotmail.com
Egypt, Dokki, Cairo, 12622; Jeddah, 21589


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