Organo Sn(IV) and Pd(II) complexes with various oxygen and sulphur donor ligands: Synthesis, spectroscopy and biological activity
- Authors: Fatima J.1, Hussain S.1, Ali S.1, Shahzadi S.1, Ramzan S.1, Shahid M.2
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Affiliations:
- Department of Chemistry
- Department of Chemistry and Biochemistry
- Issue: Vol 86, No 12 (2016)
- Pages: 2914-2923
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217463
- DOI: https://doi.org/10.1134/S1070363216120604
- ID: 217463
Cite item
Abstract
Two Pd(II) complexes, (HL1CSS)2Pd (1) and (KL2CSS)2Pd (2), were synthesized by stirring 2-(1-piperazinyl)ethanol (HL1H)/l-lysine (HL2H) monohydrate in methanol with KOH, CS2 and PdCl2(aq). Homobimetallic (Sn, Sn) products, Ph3SnL3Sn(Cl)Bu2 (3) and Ph3SnL3SnBu3 (4) were produced by refluxing sodium but-2-ynedioate (Na2L3) with Ph3SnCl and Bu2SnCl2 or Ph3SnCl and Bu3SnCl in methanol. A heteronuclear (Sn,Pd) product, [(Bu3Sn)2L2CSS]2Pd (5) was synthesized by the reaction of 5-aminoisophthalic acid (H2L4H), KOH, CS2, PdCl2(aq) with Bu3SnCl. The products were characterized by elemental analysis, FT-IR, UV-Vis, 1H NMR and EIMS. A square planar geometry of Pd(II) and a penta-coordinated environment around Sn(IV) were verified in solid state. The complexes maintain their solid state geometries around Pd(II) even in solutions. Pd(II) complexes 1 and 2 exhibited a significant intercalating mode of binding with salmon sperm DNA. ALPs were inhibited in a concentration dependent manner. Sn(IV) complexes (3 and 4) were inactive against ALPs. Pd(II) complexes (1 and 2) were potent ALPs inhibitors, while the heteronuclear complex 5 was comparatively less active. Organotin(IV) products demonstrated significant antibacterial/ antifungal potential while Pd(II) products were inactive. The heteronuclear (Sn,Pd) product demonstrated moderate inhibition. Among all products, Pd(II) derivative 1 exhibited the highest hemolytic effect.
About the authors
J. Fatima
Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Faisalabad, 40100
S. Hussain
Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Faisalabad
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Shahzadi
Department of Chemistry; Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Faisalabad, 40100; Islamabad, 45320
S. Ramzan
Department of Chemistry
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
M. Shahid
Department of Chemistry and Biochemistry
Email: drsa54@hotmail.com
Pakistan, Faisalabad